Dimethylargininase (DDAH)
Dimethylarginine Dimethylaminohydrolase
Dimethylarginase (DDAH) hydrolyzes asymmetric dimethylarginine (ADMA) to regulate the production of nitric oxide (NO) , and its two isozymes, DDAH1 and DDAH2, are expressed in various tissues. DDAH is a potential inhibitory target for diseases such as cardiovascular disease, neurodegenerative diseases, and cancer.
Referencias:
- [1]. Dimethylargininase. Neuroscience. Sciencedirect.
- [2]. Gray GA, et al. Immunolocalisation and activity of DDAH I and II in the heart and modification post-myocardial infarction. Acta Histochem. 2010 Sep;112(5):413-23. [Content Brief]
- [3]. Murphy RB, et al. Inhibitors of the Hydrolytic Enzyme Dimethylarginine Dimethylaminohydrolase (DDAH): Discovery, Synthesis and Development. Molecules. 2016 May 11;21(5):615. [Content Brief]
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PD 404182 (Standard)
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